ProTides for Antiviral Activity Beyond Liver Cells

F. Goebel, A. Humboldt, H. Kim, C. J. M. Schölzel, R. Bartenschlager, C. Richert

Chem. Eur. J. 2026
DOI: 10.1002/chem.70901

A strategy for obtaining prodrugs of antiviral nucleotides with broad tissue activity is presented that relies on cycloalkyl or cycloalkylalkyl esters, improving uptake and esterase cleavage, and producing nanomolar inhibitors in kidney, colon, and lung cells.

 

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