Bastian Joffroy, Yavuz O Uca, Domen Prešern, Jonathan P. K Doye, Thorsten L Schmidt

Acids Research, Volume 46, Issue 2, 25 2018, Pages 538–545

Small DNA circles can serve as templates for rolling circle amplification (RCA), which is a common and extremely robust amplification mechanism for nucleic acids. We discovered a strong template length-dependent amplification efficiency bias of RCA with the same periodicity as B-DNA.