Controlling Coagulation in Blood with Red Light

Patricia Müller, Marlen Sahlbach, Simone Gasper, Prof. Dr. Günter Mayer, Priv.-Doz. Dr. Jens Müller, Prof. Dr. Bernd Pötzsch, Prof. Dr. Alexander Heckel

Angew. Chem. Int. Ed. 2021, 60, 22441. (open access)

An engineered aptamer with a Cy7-based photocleavable linker can be used as anticoagulant. With tissue-penetrating red light, the aptamer is cleaved, and blood clotting is restored in human whole blood.