Controlling Coagulation in Blood with Red Light

Patricia Müller, Marlen Sahlbach, Simone Gasper, Prof. Dr. Günter Mayer, Priv.-Doz. Dr. Jens Müller, Prof. Dr. Bernd Pötzsch, Prof. Dr. Alexander Heckel

Angew. Chem. Int. Ed. 2021, 60, 22441.
https://doi.org/10.1002/anie.202108468 (open access)

An engineered aptamer with a Cy7-based photocleavable linker can be used as anticoagulant. With tissue-penetrating red light, the aptamer is cleaved, and blood clotting is restored in human whole blood.


 

 

Paper Highlights
  • Quality Control of mRNA Vaccines by Synthetic Ribonucleases: Analysis of the Poly-A-Tail

    Weiterlesen: ...

  • Ribosome-free translation up to pentapeptides via template walkon RNA sequences

    Weiterlesen: ...

  • Solid-Phase-Supported Chemoenzymatic Synthesis of a Light-Activatable tRNA Derivative

    Weiterlesen: ...

  • Controlling Coagulation in Blood with Red Light

    Weiterlesen: ...

  • Thoughts on What Chemists Can Contribute to Fighting SARS-CoV-2 - A Short Note on Hand Sanitizers, Drug Candidates and Outreach

    Weiterlesen: ...