Quality Control of mRNA Vaccines by Synthetic Ribonucleases: Analysis of the Poly-A-Tail

Felix Zellmann, Nina Schmauk, Nina Murmann, Madeleine Böhm, Alexander Schwenger, Michael Göbel

ChemBioChem 2024, 25, e202400347
https://doi.org/10.1002/cbic.202400347 (open access)

Oligonucleotide conjugates of tris(2-aminobenzimidazoles), known as potent and sequence-specific RNA cleavers, are applied as analytical tools to check the poly-A tail and the 5’ terminus of mRNA vaccines.

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Quality Control of mRNA Vaccines by Synthetic Ribonucleases: Analysis of the Poly-A-Tail
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